Caenorhabditis elegans is widely used as a drug screening and research model in various research fields, such as developmental biology, chemical biology, fat metabolism and obesity, aging, neurodegenerative diseases, environmental toxicology, and cancer research. Because the nematode is very small (the adult is only about 1 mm), the different drug administration methods lead to different drug absorption efficiency, so there are differences between different research results and it is difficult to make comparative analysis.
The research group of Luo Huairong of Kunming Institute of Botany, Chinese Academy of Sciences used low-water resveratrol and water-soluble fluorouridine (FUDR) as reference drugs. Five common methods of administration were used to treat nematodes separately. And the absorption efficiency of water-soluble drugs reveals the law of drug absorption and metabolism under different administration methods of nematodes. The results of the study showed that the concentrations of resveratrol and FUDR gradually increased in the nematodes cultured by the five methods of administration, reached the highest in 12-24 hours, and slowly decreased with the cultivation time. At the same time, the higher the administered concentration, the faster the nematode metabolism and efflux. Nematodes have similar absorption and metabolism patterns for low-water resveratrol and water-soluble FUDR. Because the drug in the culture medium used for cultivating nematodes is absorbed by live bacteria, the concentration of the drug in the culture medium decreases rapidly, and the absorption efficiency of the nematode edible bacteria is higher than that when the edible bacteria are alive. Among the five culture methods, the nematodes cultured by NGM dead method and liquid growing method have the highest efficiency of absorbing drugs. The drug concentration in the nematode can be converted into the dose of the drug in the mouse, which provides a bridge between the dose of the nematode and the dose of the mammal.
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